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KMID : 0613820110210030459
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Journal of Life Science
2011 Volume.21 No. 3 p.459 ~ p.463
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Molecular Analysis of Alternative Transcripts of CCDC94 Gene in the Brain Tissues of Rhesus Monkey
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Yun Se-Eun
Ahn Kung
Kim Heui-Soo
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Abstract
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The genome of the rhesus monkey has diverged as an average sequence identity of ~93%. The rhesus monkey has been widely used as a non-human primate in the field of biomedical and evolutional research. Insertion of transposable elements (TEs) induced several events such as transcriptional diversity and different expression in host genes. In this study, 112 transcripts were identified from a full-length cDNA library of brain tissues of the rhesus monkey. One transcript (R54) showed a different expression pattern between human and rhesus monkey tissues. This phenomenon can be an explanation that R54 transcript was acquired by splicing a donor site derived from exonization of the L2A element. Therefore, integration of TEs during primate radiation could contribute to transcriptional diversity and gene regulation.
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KEYWORD
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Rhesus monkey, brain cDNA library, CCDC94, gene expression, alternative splicing, primates
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